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N-Piperidinyl Etonitazene: A Comprehensive Guide to This New Drug
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N-Piperidinyl Etonitazene: A Comprehensive Guide to This New Drug

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Keith Graves
Nov 22, 2021
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N-Piperidinyl Etonitazene: A Comprehensive Guide to This New Drug
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Introduction: What is N-Piperidinyl Etonitazene?

N-Piperidinyl Etonitazene is classified as a novel opioid. A novel opioid is a Novel Psychoactive Substance (NPS) with one NPS arriving on the market each week. These are chemicals made in a laboratory (usually in China) and shipped to the United States for consumption.

Structurally similar compounds include etonitazene, metonitazene, and isotonitazene. N-piperidinyl Etonitazene is a chemical compound that was created in the 1950s by researchers at Pfizer. Data suggest that this group of analogues can have potency similar to or greater than fentanyl.

Recent in vitro data suggest that N-piperidinyl etonitazene is slightly less potent than etonitazene but more potent than fentanyl (unpublished data from M. Vandeputte and C. Stove). N-Piperidinyl Etonitazene is not explicitly scheduled in the United States; however, etonitazene and isotonitazene are Schedule I substances.

N-Piperidinyl Etonitazene will usually appear as a crystalline powder. 

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The Risks of Using N-Piperidinyl Etonitazene

Novel opioids have been reported to cause psychoactive effects similar to heroin, fentanyl, and other opioids. Novel opioids have also caused adverse events, including death. Like most opioids, Narcan can reverse an overdose.

Intelligence Analysis

This is a drug that may come up occasionally, but will be rarely seen, if at all, by most officers. With that said, there will more than likely be overdoses in the United States with this drug because of its potency. Officers should be aware of it for this reason alone. 


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New Fentanyl Analog Entered the Drug Supply: ortho-Methylfentanyl
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