The illicit use of ketamine, a powerful anesthetic often abused for its hallucinogenic effects, is on the rise in the United States. A recent analysis published in JAMA Psychiatry revealed a 349% increase in the number of ketamine seizures by law enforcement agencies between 2017 and 2022. The total weight of ketamine seized saw an even more staggering increase, rising by 1,116.4% during the same period.