The Drug Enforcement Administration (DEA) has issued a notice of intent for a temporary amendment concerning two perilous synthetic benzimidazole-opioid substances: N-desethyl isotonitazene and N-piperidinyl etonitazene. The emergence and abuse of these substances have posed significant risks, leading to severe health complications and a rising number of fatalities. This initiative by the DEA aims to curb the distribution and misuse of these dangerous substances, marking a step towards addressing the ongoing opioid crisis.